Endocrine Abstracts

Objectives: Maternal hypothyroidism in pregnancy has been proposed to increase the risk of preeclampsia, but uncertainties persist regarding the underlying causal mechanisms. Thus, it remains unclear if an increased risk of preeclampsia in hypothyroid pregnant women is caused by the lack of thyroid hormones or by the thyroid autoimmunity per se.Methods: We performed a national and regional study in the Danish population. The national study was r...

Objectives: Thyroid disease in women of reproductive age is predominantly of autoimmune origin, and thyroid peroxidase antibodies (TPO-Ab) as well as thyroglobulin antibodies (Tg-Ab) are key markers of autoimmune hypothyroidism. Adding to this, much focus in pregnancy is on euthyroid women who are positive for thyroid autoantibodies. The observational findings are diverse, and evidence to substantiate the applied cut-offs for definition of thyroid autoantibody-positivity in ea...